Both Phosphonic Acid- and Fluorine-Containing Poly(aryl ether)–hydroxyapatite Biocomposites: Toward Enhanced Biocompatibility and Bonelike Elastic Modulus,ACS Applied Bio Materials

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Both Phosphonic Acid- and Fluorine-Containing Poly(aryl ether)–hydroxyapatite Biocomposites: Toward Enhanced Biocompatibility and Bonelike Elastic Modulus
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-11-19 , DOI: 10.1021/acsabm.0c01254
Xunyuan Jiang ₁ , Yitong Yao ₂ , Weiming Tang ₁ , Dongmei Han ₁ , Li Zhang ₃ , Ke Zhao ₂ , Shuanjin Wang ₁ , Yuezhong Meng ₁

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Metal-based implants possess excellent mechanical strength, corrosion resistance, and biocompatibility and can deliver favorable performances in clinic treatments. However, modulus mismatching is considered a common defect for metal-based materials, while polymer-based materials with a bonelike elastic modulus have been regarded as one of the most promising candidates for bone replacement implants. In this work, a phosphonic acid- and fluorine-containing poly(aryl ether) (PAE) resin is designed and synthesized, which is determined to be an amorphous polymer with excellent thermostability. The elastic modulus of composites is improved to 15.7 GPa by reinforcing with 60 wt % hydroxyapatite (HA), which demonstrates admirable protein adsorption and hydrophilicity. After 14 days of immersion in simulated body fluid, a layer of HA deposition can be observed, indicating favorable bioactivity in advance, and the preliminary in vitro cell experiments also suggest that PAE-HA composites possess favorable cell responses on adhesion, proliferation, and differentiation, which reveal the feasibility of synthesized polymers to be employed as bone replacement materials, while the adjustability in molecular chains also leaves room for further investigations.

中文翻译：

含膦酸和含氟聚（芳基醚）-羟基磷灰石生物复合材料：提高生物相容性和骨样弹性模量

金属基植入物具有优异的机械强度、耐腐蚀性和生物相容性，可在临床治疗中提供良好的性能。然而，模量不匹配被认为是金属基材料的常见缺陷，而具有类骨弹性模量的聚合物基材料被认为是骨替代植入物最有希望的候选材料之一。在这项工作中，设计和合成了一种含膦酸和氟的聚芳醚（PAE）树脂，该树脂被确定为具有优异热稳定性的无定形聚合物。通过用 60 wt% 的羟基磷灰石 (HA) 增强，复合材料的弹性模量提高到 15.7 GPa，这表现出令人钦佩的蛋白质吸附和亲水性。在模拟体液中浸泡 14 天后，

更新日期：2020-12-21

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