A Lyotropic Liquid Crystal from a Flexible Oligopeptide Amphiphile in Dimethyl Sulfoxide,ACS Applied Bio Materials

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A Lyotropic Liquid Crystal from a Flexible Oligopeptide Amphiphile in Dimethyl Sulfoxide
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-11-18 , DOI: 10.1021/acsabm.0c01231
Wen-Qiang Ding ₁ , Han Liu ₂ , Si-Yong Qin ₁ , Yan Jiang ₁ , Xinxiang Lei _{1,

2} , Ai-Qing Zhang ₁

Affiliation

Despite the rapid progress in peptide liquid crystals (LCs) due to their prominent properties, our investigation on flexible peptide-based LCs is incomplete, mainly resulted from their unclear formation mechanisms and unexploited applications in organic solvents. Here, we develop a lyotropic LC based on a flexible oligopeptide amphiphile, which aggregates into aligned cylinder-like nanostructures in dimethyl sulfoxide (DMSO). The formation mechanism of lyotropic LC in DMSO was probed by the experimental investigation and molecular dynamics simulation, indicating that the hydrogen bonding and hydrophobic and electrostatic interactions contribute to the formation of ordered nanostructures in the organic solvent. Arising from the orientational order and suitable fluidity, we exploit the application of lyotropic LC as an aligned medium to measure the residual dipolar couplings of bioactive molecules. This study not only offers the understanding of the mechanism to create LC systems without rigid aromatic groups but also expands the applications of ordered bottom-up nanomaterials in organic solvents.

中文翻译：

来自二甲基亚砜中的柔性寡肽两亲物的溶致液晶

尽管肽液晶 (LCs) 因其突出的特性而取得了快速进展，但我们对基于柔性肽的 LCs 的研究并不完整，这主要是由于它们的形成机制尚不清楚以及在有机溶剂中的未开发应用。在这里，我们开发了一种基于柔性寡肽两亲物的溶致 LC，它在二甲基亚砜 (DMSO) 中聚集成排列的圆柱状纳米结构。通过实验研究和分子动力学模拟探讨了溶致LC在DMSO中的形成机制，表明氢键和疏水和静电相互作用有助于在有机溶剂中形成有序的纳米结构。源于定向秩序和适宜的流动性，我们利用溶致 LC 作为对齐介质的应用来测量生物活性分子的残余偶极耦合。该研究不仅提供了对创建不含刚性芳族基团的 LC 系统的机制的理解，而且扩展了有序自下而上纳米材料在有机溶剂中的应用。

更新日期：2020-12-21

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