ANIPE-Cu Catalyst Enables Highly Enantioselective Markovnikov Hydroboration of α-Olefins,Synlett

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ANIPE-Cu Catalyst Enables Highly Enantioselective Markovnikov Hydroboration of α-Olefins
Synlett ( IF 1.7 ) Pub Date : 2020-11-18 , DOI: 10.1055/s-1288-2990
Shi-Liang Shi ₁ , Yuan Cai

Affiliation

Asymmetric hydroboration of simple and unactivated terminal alkenes (α-olefins), feedstock chemicals derived from the petrochemical industry, has not been efficiently realized for past decades. Using a bulky ANIPE ligand, we achieved a rare example of highly enantioselective copper-catalyzed Markovnikov hydroboration of α-olefins. The chiral secondary alkylboronic ester products were obtained in moderate to good yields and regioselectivities with excellent enantioselectivities.

1 Introduction

2 Conditions Optimization

3 Substrate Scope

4 Application

5 Mechanistic Discussion

6 Conclusions and Future Directions

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