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ANIPE-Cu Catalyst Enables Highly Enantioselective Markovnikov Hydroboration of α-Olefins
Synlett ( IF 1.7 ) Pub Date : 2020-11-18 , DOI: 10.1055/s-1288-2990
Shi-Liang Shi 1 , Yuan Cai
Affiliation  

Asymmetric hydroboration of simple and unactivated terminal alkenes (α-olefins), feedstock chemicals derived from the petrochemical industry, has not been efficiently realized for past decades. Using a bulky ANIPE ligand, we achieved a rare example of highly enantioselective copper-catalyzed Markovnikov hydroboration of α-olefins. The chiral secondary alkylboronic ester products were obtained in moderate to good yields and regioselectivities with excellent enantioselectivities.

1 Introduction

2 Conditions Optimization

3 Substrate Scope

4 Application

5 Mechanistic Discussion

6 Conclusions and Future Directions



中文翻译:

ANIPE-Cu催化剂可实现α-烯烃的高度对映选择性马尔可夫尼科夫硼氢化反应

简单和未活化的末端烯烃(α-烯烃)(一种来自石油化学工业的原料化学品)的不对称加氢硼化在过去几十年中尚未得到有效实现。使用庞大的ANIPE配体,我们获得了稀有的高对映选择性铜催化α-烯烃马氏化学硼氢化的例子。以中等至良好的产率和区域选择性以及优异的对映选择性获得手性仲烷基硼酸酯产物。

1引言

2条件优化

3基板范围

4申请

5机制讨论

6结论和未来方向

更新日期:2020-11-19
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