T he Human Face of ABCC6,FEBS Letters

当前位置： X-MOL 学术 › FEBS Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

T he Human Face of ABCC6
FEBS Letters ( IF 3.0 ) Pub Date : 2020-12-01 , DOI: 10.1002/1873-3468.14002
Sharon F. Terry ₁

Affiliation

Researchers working on basic and translational clinical science related to ABC transporters are enthusiastic and dedicated investigators. As the field has grown, so has its contribution to human disease. Pseudoxanthoma elasticum (PXE) International, an advocacy organization established by non‐scientists, began supporting research and convenings on these transporters, specifically ABCC6, the gene associated with PXE, 20 years ago. As a patient advocacy organization, we have spent more than 25 years creating a large research consortium, initiating, funding and conducting research. Years of basic modelling and vigorous hypothesis testing have resulted in some important advances leading to clinical trials. The synergy of basic scientists, lay advocates, clinicians and translational scientists has dramatically accelerated research on PXE and progress towards better and more effective treatments for PXE patients.

中文翻译：

ABCC6 的人脸

从事与 ABC 转运蛋白相关的基础和转化临床科学的研究人员是热情而敬业的研究人员。随着该领域的发展，它对人类疾病的贡献也在增加。弹性假黄瘤 (PXE) 国际是一个由非科学家建立的倡导组织，20 年前开始支持这些转运蛋白的研究和召集，特别是与 PXE 相关的基因 ABCC6。作为患者倡导组织，我们花了超过 25 年的时间创建了一个大型研究联盟，发起、资助和开展研究。多年的基本建模和有力的假设检验已经取得了一些重要的进展，导致了临床试验。基础科学家、外行倡导者的协同作用，

更新日期：2020-12-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11