Rest (RE1‐silencing transcription factor, also called Nrsf) is involved in the maintenance of the undifferentiated state of neuronal stem/progenitor cells by preventing precocious expression of neuronal genes. In order to further investigate the function of Rest in neurons, we generated and examined mice evoking genetic ablation of Rest specifically in neural tissues by generating Rest conditional knockout mice. As the Rest knockout mice are embryonically lethal, we used a Sox1‐Cre allele to excise the floxed Rest gene from the early stage of nerve cell differentiation including neural crest‐derived nerve cells. Using this conditional Rest knockout Sox1‐Cre; Rest^flox/flox mice, we have revealed the role of Rest in the parasympathetic nervous system in the stomach and heart

中文翻译：

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Rest 的诱导基因消融导致迷走神经刺激诱导反应的改变

Rest（RE1 沉默转录因子，也称为 Nrsf）通过阻止神经元基因的早熟表达来参与维持神经元干细胞/祖细胞的未分化状态。为了进一步研究Rest在神经元中的功能，我们通过生成Rest条件性敲除小鼠，生成并检查了在神经组织中引起Rest基因消融的小鼠。由于Rest基因敲除小鼠具有胚胎致死性，我们使用Sox1-Cre等位基因从神经细胞分化的早期阶段切除了 floxed Rest基因，包括神经嵴衍生的神经细胞。使用这个有条件的 Rest淘汰赛Sox1-Cre; Rest ^flox/flox小鼠，我们揭示了Rest在胃和心脏的副交感神经系统中的作用