Gene expression responses to Zika virus infection in peripheral blood mononuclear cells from pregnant and non‐pregnant women,MicrobiologyOpen

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Gene expression responses to Zika virus infection in peripheral blood mononuclear cells from pregnant and non‐pregnant women
MicrobiologyOpen ( IF 3.9 ) Pub Date : 2020-11-19 , DOI: 10.1002/mbo3.1134
Shen Jean Lim ₁ , Andreas Seyfang ₂ , Samia Dutra ₁ , Bradley Kane ₁ , Maureen Groer ₁

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Congenital Zika syndrome is caused by mother‐to‐fetus transmission of the Zika virus (ZIKV). Peripheral blood mononuclear cells (PBMCs) are permissive to ZIKV infection and may carry ZIKV to the placenta. To identify pregnancy‐related differences in PBMC responses against ZIKV infection, we compared gene expression profiles of ZIKV‐infected and non‐infected PBMCs cultured from pregnant and non‐pregnant women. ZIKV‐infected pregnant conditions generally overexpressed M1‐shifted pro‐inflammatory responses and underexpressed M2‐shifted anti‐inflammatory responses. Additionally, transcripts involved in osteoclast differentiation and cardiac myopathies were upregulated following ZIKV infection. Our results suggest potential roles of pregnancy‐induced immune dysregulation in shaping neonatal pathology associated with ZIKV infection.

中文翻译：

孕妇和非孕妇外周血单个核细胞对寨卡病毒感染的基因表达反应

先天性寨卡综合征是由寨卡病毒 (ZIKV) 的母婴传播引起的。外周血单个核细胞 (PBMC) 允许 ZIKV 感染，并可能将 ZIKV 携带到胎盘。为了确定 PBMC 对 ZIKV 感染反应的妊娠相关差异，我们比较了从孕妇和非孕妇培养的 ZIKV 感染和未感染 PBMC 的基因表达谱。ZIKV 感染的妊娠状况通常过度表达 M1 转移的促炎反应，而 M2 转移的抗炎反应则低表达。此外，在 ZIKV 感染后，参与破骨细胞分化和心肌病的转录本上调。我们的研究结果表明妊娠引起的免疫失调在塑造与 ZIKV 感染相关的新生儿病理方面的潜在作用。

更新日期：2020-12-23

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