In article number 2002680, Jun Cui and co‐workers identify a new histone modifier‐USP38, that modulates histone ubiquitination and methylation to resolve inflammatory response. USP38 acts as a “Safety Machine” which shuts down the inflammation by de‐ubiquitinating histone H2B and stabilizes KDM5B to de‐methylate H3K4, which blocks the transcription of pro‐inflammatory genes. The USP38‐KDM5B complex might be a potential clinical target for therapy against inflammatory diseases.

中文翻译：

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炎症反应：USP38通过KDM5B偶联组蛋白泛素化和甲基化以解决炎症（Adv。Sci。22/2020）

崔军及其同事在文章编号2002680中，确定了一种新的组蛋白修饰剂USP38，它可以调节组蛋白的泛素化和甲基化以解决炎症反应。USP38充当“安全机器”，通过去泛素化组蛋白H2B来关闭炎症，并使KDM5B稳定以使H3K4去甲基化，从而阻止促炎基因的转录。USP38-KDM5B复合物可能是抗炎性疾病的潜在临床靶标。