当前位置: X-MOL 学术Trends Anal. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Voltammetric biosensors for analytical detection of cardiac troponin biomarkers in acute myocardial infarction
Trends in Analytical Chemistry ( IF 11.8 ) Pub Date : 2020-11-19 , DOI: 10.1016/j.trac.2020.116123
Ali Pourali , Mohammad Reza Rashidi , Jaleh Barar , Graciela Pavon-Djavid , Yadollah Omidi

The fast and precise diagnosis of acute myocardial infarction (AMI) is of great importance for the survival of patients. Here, we provide key insights into the recent progress in amperometry/voltammetry biosensors for the detection of AMI. Voltammetry-based biosensors have been developed to simultaneously detect multiplexed biomarkers, which can also serve as beneficial point-of-care diagnostic devices, and provide fast and cost-efficient tools for monitoring of biomarkers involved in AMI such as cardiac troponin (cTn I, cTnT) isoforms. Various voltammetry labeled and label-free techniques are articulated, and enzymatic and non-enzymatic systems are delineated with emphasis on the structural details and figures of merits of these methods. Much more robust and sensitive voltammetric biosensors are prognosticated to be developed by the integration of nanoscale advanced materials and progress in engineering through merging microfluidics in voltammetric techniques. Altogether, it is envisioned that the voltammetric biosensors be translated into clinical practice soon.



中文翻译:

伏安生物传感器用于急性心肌梗死中心肌肌钙蛋白生物标志物的分析检测

快速准确地诊断急性心肌梗死(AMI)对于患者的生存至关重要。在这里,我们提供了对用于检测AMI的安培/伏安法生物传感器的最新进展的关键见解。已开发出基于伏安法的生物传感器,可同时检测多种生物标志物,这些生物标志物还可以用作有益的即时诊断工具,并提供快速,经济高效的工具来监测AMI中涉及的生物标志物,例如心肌肌钙蛋白(cTn I, cTnT)亚型。阐明了各种伏安法标记的和无标记的技术,并着重描述了这些方法的结构细节和优点,描绘了酶促和非酶促系统。通过集成纳米级先进材料以及通过将微流体技术整合到伏安技术中,在工程上的进步,预示着将开发出更强大,更灵敏的伏安生物传感器。总的来说,可以预见到伏安生物传感器将很快转化为临床实践。

更新日期:2020-11-19
down
wechat
bug