In this issue of Molecular Cell, Byun et al. (2020) find that the dual targeting of glutamine metabolism and the PD-L1 checkpoint inhibitor augments anti-tumor immunity. Mechanistically, decreased glutamine availability attenuated S-glutathionylation of SERCA, resulting in an increase in cytosolic calcium, enhanced NF-κB activity, and upregulation of programmed death-ligand 1.

中文翻译：

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瞄准谷氨酰胺代谢和PD-L1：一种新型的抗肿瘤双人舞

在本期《分子细胞》中，Byun等人。（2020）发现谷氨酰胺代谢和PD-L1检查点抑制剂的双重靶向增强了抗肿瘤免疫力。从机制上讲，降低的谷氨酰胺可利用性会削弱SERCA的S-谷胱甘肽化，从而导致细胞内钙的增加，NF-κB活性的增强以及程序性死亡配体1的上调。