Cancer/Testis Antigens (CTAs) genes are expressed only during spermatogenesis and tumorigenesis. Both processes share common specific metabolic adaptation related to energy supply, with a glucose to lactate gradient, leading to changes in mitochondrial physiology paralleling CTAs expression. In this review, we address the role of CTAs in mitochondria (mitoCTAs), by reviewing all published data, and assessing the putative localization of CTAs by screening for the presence of a mitochondrial targeting sequence (MTS). We evidenced that among the 276 CTAs, five were already shown to interfere with mitochondrial activities and 67 display a potential MTS.

中文翻译：

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癌症/睾丸抗原进入线粒体：精子发生、肿瘤发生和线粒体生理适应之间的枢纽

癌症/睾丸抗原 (CTA) 基因仅在精子发生和肿瘤发生期间表达。这两个过程共享与能量供应相关的共同特定代谢适应，具有葡萄糖到乳酸梯度，导致与 CTA 表达平行的线粒体生理变化。在本次审查中，我们通过审查所有已发表的数据并通过筛选线粒体靶向序列 (MTS) 的存在来评估 CTA 的假定定位，从而解决 CTA 在线粒体 (mitoCTA) 中的作用。我们证明，在 276 个 CTA 中，5 个已经显示出干扰线粒体活动，67 个显示出潜在的 MTS。