Periodontitis is a high prevalent disease into the clinical dentistry. Genetic variations in interleukins (IL) genes were associated with chronic periodontitis (CP) and were focus of several meta-analyses. This study aimed to assess the noteworthiness in the meta-analyses by means of a Bayesian approach to determinate possible false report associations. A systematic search was performed for meta-analyses with associations between gene polymorphisms in interleukins and CP. The calculations for the False-Positive Rate Probability (FPRP) and the Bayesian False Discovery Probability (BFDP) were performed to assess the noteworthiness with a statistical power of 1.2 and 1.5 of Odds Ratio at a prior probability of 10-3 and 10-6. As results, eight meta-analyses approaching the IL1A/rs1800587, IL1B/rs1143634, IL1RN/rs2234663, IL4/rs2243250, IL6/rs1800795/rs1800796, IL17A/rs2275913 and IL18/rs1946518/rs187238 polymorphisms have been identified. Twenty-two from 270 calculations (8.15%) were noteworthy. Herein, we have identified the IL1A and IL1B polymorphisms as noteworthy biomarkers for CP susceptibility.

中文翻译：

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白细胞介素基因多态性与慢性牙周炎：贝叶斯方法的领域概要和重估

牙周炎是临床牙科中的高发疾病。白细胞介素 (IL) 基因的遗传变异与慢性牙周炎 (CP) 相关，是几项荟萃分析的重点。本研究旨在通过贝叶斯方法评估荟萃分析中的重要性，以确定可能的虚假报告关联。对白细胞介素和 CP 基因多态性之间关联的荟萃分析进行了系统搜索。对假阳性率概率 (FPRP) 和贝叶斯错误发现概率 (BFDP) 进行了计算，以在先验概率为 10-3 和 10-6 的情况下以优势比的 1.2 和 1.5 的统计功效评估显着性. 结果，八项荟萃分析接近 IL1A/rs1800587、IL1B/rs1143634、IL1RN/rs2234663、IL4/rs2243250、已鉴定出 IL6/rs1800795/rs1800796、IL17A/rs2275913 和 IL18/rs1946518/rs187238 多态性。270 次计算中的 22 次（8.15%）值得注意。在此，我们已将 IL1A 和 IL1B 多态性鉴定为 CP 易感性的值得注意的生物标志物。