Activation of innate immune signaling in the tumor microenvironment is central to a successful anti-tumor immune response, and it is in large part mediated by cytosolic double-stranded DNA sensing. Here, Carozza et al. (2020b) report potent and selective inhibitors of ENPP1, a negative regulator of innate immune signaling, which are shown to potentiate anti-tumor immune responses.

中文翻译：

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重新唤醒癌症中的先天免疫信号：高效 ENPP1 抑制剂的开发

肿瘤微环境中先天免疫信号的激活是成功抗肿瘤免疫反应的核心，它在很大程度上是由胞质双链 DNA 传感介导的。在这里，卡罗扎等人。(2020b) 报告了 ENPP1 的有效和选择性抑制剂，ENPP1 是先天免疫信号传导的负调节因子，被证明可以增强抗肿瘤免疫反应。