Chemotherapeutic treatments are frequently impeded by the development of multidrug resistance (MDR). In this issue of Cell Chemical Biology, Wang et al. (2020) identify the natural product verucopeptin as having therapeutic potential toward MDR cancer cell types by targeting v-ATPase and mTORC1 signaling.

中文翻译：

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v-ATPase和mTORC1信号的双重靶向解除了多药耐药癌症的武器

多药耐药性（MDR）的发展经常阻碍化学疗法的治疗。在本期《细胞化学生物学》中，Wang等人。（2020）通过靶向v-ATPase和mTORC1信号传导确定天然产物Verucopeptin对MDR癌细胞类型具有治疗潜力。