Solid dispersions of medamine and albendazole with water-soluble polymers (PVP, arabinogalactan) were obtained by mechanochemical technology to increase the aqueous solubility of poorly soluble anthelmintic drug substances. An analysis of solid dispersions of drug–polymer systems showed that their solubilities depended on the nature of both the drug and polymer. The aqueous solubilities of medamine and albendazole could be increased by greater than 50 and 27 times, respectively, by varying the joint processing time with the polymers. An analysis of IR spectra and a comparison of them with published data suggested that intermolecular complexes were formed in these systems. Innovative anthelmintic drugs with increased solubility for medicine and veterinary medicine could be created by using the proposed mechanochemical technology for obtaining solid dispersions. The resulting solid dispersions had several advantages over conventional dosage forms, in particular, they were obtained in one stage, their preparation did not require excipients (dispersants, surfactants, wetting agents, etc.), and they were more conveniently used and inexpensively priced.

通过机械化学技术获得了三聚氰胺和阿苯达唑与水溶性聚合物（PVP，阿拉伯半乳聚糖）的固体分散体，以提高难溶性驱虫药的水溶性。对药物-聚合物系统的固体分散体的分析表明，它们的溶解度取决于药物和聚合物的性质。通过改变与聚合物的联合处理时间，可将美胺和阿苯达唑的水溶性分别提高50倍和27倍以上。红外光谱分析和与已发表数据的比较表明，在这些系统中形成了分子间复合物。通过使用建议的机械化学技术获得固体分散体，可以生产出对药物和兽药具有更高溶解度的创新驱虫药。所得的固体分散体相对于常规剂型具有多个优点，特别是它们是在一个阶段中获得的，其制备不需要赋形剂（分散剂，表面活性剂，湿润剂等），并且它们使用更方便且价格便宜。