Purpose

Previous studies have suggested improved recanalization efficiency by using cyclic aspiration as opposed to static aspiration for mechanical thrombectomy in the treatment of acute ischemic stroke (AIS). However, there has not been an investigation into which parameters optimize this theoretical approach. Therefore, this study was designed to investigate the application of static and cyclic pressure in AIS aspiration catheters.

Methods

An experimental flow system was designed to apply and measure both static and cyclic aspiration pressures in four commercial aspiration catheters. A medical aspirator and solenoid-valve were used to generate a range of applied pump pressures and cyclic valve frequencies. The measured mean and oscillatory pressure amplitudes were analyzed and compared across catheters and operating conditions.

Results

The greatest mean pressures and forces were achieved under contact-aspiration conditions using the largest diameter catheter, while the largest oscillating pressure (ΔP) and force (ΔF) values were generated in the least compliant catheter, determined to be proportional to both its inner radius and wall thickness. Furthermore, lower frequency cyclic aspiration was able to generate the largest values of ΔP and ΔF.

Conclusion

For future investigations of cyclic aspiration AIS therapy, the best options are to use large inner diameter and low compliance catheters operating at lower cyclic frequencies to generate the greatest mean and oscillating forces on lodged thromboemboli.

中文翻译：

---

静态和循环抽吸条件下急性缺血性卒中导管的流体动力学

目的

先前的研究表明，在治疗急性缺血性中风 (AIS) 时，通过使用循环抽吸而不是静态抽吸进行机械取栓可以提高再通效率。然而，还没有研究哪些参数优化了这种理论方法。因此，本研究旨在研究静压和循环压力在 AIS 抽吸导管中的应用。

方法

一个实验流量系统被设计用于在四个商业抽吸导管中应用和测量静态和循环抽吸压力。医用抽吸器和电磁阀用于产生一系列施加的泵压力和循环阀频率。跨导管和操作条件分析和比较测量的平均和振荡压力幅度。

结果

最大的平均压力和力是在接触抽吸条件下使用最大直径的导管实现的，而最大的振荡压力 ( ΔP ) 和力 ( ΔF ) 值是在顺应性最低的导管中产生的，确定与其两者成正比内半径和壁厚。此外，较低频率的循环抽吸能够产生最大的 Δ P和 Δ F 值。

结论

对于循环抽吸 AIS 治疗的未来研究，最好的选择是使用大内径和低顺应性导管，以较低的循环频率运行，以对卡住的血栓栓塞产生最大的平均和振荡力。