Because the mechanism of tissue-specific toxicity of tributyltin (TBT) in aquatic organisms has not been explained clearly, the aim of this study is to investigate the effect of chronic exposure to TBT on muscle-related energy metabolism, gill-related ATPase enzymatic system and intestine-related digestive enzymes activities in zebrafish. Male zebrafish were exposed to sub-lethal concentrations of TBT (10, 100 and 300 ng/L) for 6 weeks. Multiple biomarkers were measured (such as glucose, lactate, hexokinase, pyruvate kinase, lactate dehydrogenase, ATP content, ATPases, trypsin, lipase and amylase), which reflected more serious physiological stress with increasing TBT concentrations during the experimental period. Through principal component analysis (PCA) and integrated biomarker response (IBR) analysis, the toxic effect of TBT in zebrafish was in a concentration-dependent manner. Shortly, the results of this study can provide new evidence for a comprehensive understanding of the toxic effects of TBT.

由于尚未明确解释水生生物中三丁基锡（TBT）的组织特异性毒性机制，因此本研究的目的是研究长期暴露于TBT对肌肉相关的能量代谢，g相关的ATPase酶系统的影响。和斑马鱼肠道相关的消化酶活性。雄性斑马鱼暴露于亚致死浓度的TBT（10、100和300 ng / L）中达6周。测量了多种生物标志物（例如葡萄糖，乳酸，己糖激酶，丙酮酸激酶，乳酸脱氢酶，ATP含量，ATPase，胰蛋白酶，脂肪酶和淀粉酶），反映出在实验期间随着TBT浓度的增加，生理压力更加严重。通过主成分分析（PCA）和综合生物标记反应（IBR）分析，TBT对斑马鱼的毒性作用是浓度依赖性的。不久，这项研究的结果可以为全面了解TBT的毒性作用提供新的证据。