Recent developments in the field of sensing and recognition revealed that artificial receptors based on calix[4]arenes with π-conjugated fluorophoric or chromophoric moieties are efficient in enhancing selectivity/sensitivity as well as the binding affinity for ionic or molecular recognition. Herein, via studying the reaction of dimethylformamide dimethyl acetal (DMF–DMA) with p-tert-butylthiacalix[4]arene tetrahydrazides in three different conformers (i.e., cone, partial-cone, and 1,3-alternate), the formation of novel lower rim p-tert-butylthiacalix[4]arene derivative (cone, partial-cone, and 1,3-alternate) conformers in high yields (80, 95, and 85%, respectively) was achieved. The structure of isolated products was confirmed using different spectroscopic and analytical techniques such as FT-IR, 1H NMR, 13C NMR, and elemental analysis. Importantly, the synthesized receptors showed preferential uptakes of alkali (Na+, K+ and Cs+), heavy (Pb2+, Cd2+, Hg2+, and Ag+) and transition (Ni2+, Co2+, and Cu2+) metal ions via liquid–liquid extraction method. The finding of this work adds new compounds to the growing family of thiacalix[4]arenes and validates their high sensitivity and selectivity in detection of heavy metal ions.

中文翻译：

---

探讨N，N-二甲基甲酰胺二甲基缩醛与

传感和识别领域的最新进展表明，基于杯[4]芳烃与π共轭的荧光或发色部分的人工受体可有效提高选择性/敏感性以及对离子或分子识别的结合亲和力。在本文中，通过研究的二甲基甲酰胺反应二甲基缩醛（DMF-DMA）与p -叔-butylthiacalix [4]芳烃在三个不同的构象异构体tetrahydrazides（即，锥体，局部-锥体，和1,3-交替），形成新型下缘对-叔丁基硫杂杯[4]芳烃衍生物（锥，部分-以高产率（分别为80％，95％和85％）获得了锥和1,3-交替构象异构体。使用不同的光谱和分析技术（例如FT-IR，1 H NMR，13 C NMR和元素分析）确认了分离产物的结构。重要的是，合成的受体优先吸收碱金属（Na + ，K +和Cs + ），重金属（Pb 2 + ，Cd 2 + ，Hg 2+和Ag + ）和过渡金属（Ni 2 + ，Co 2+ ，和Cu 2+）通过液-液萃取法获得金属离子。这项工作的发现为不断增长的硫杂杯[4]芳烃家族增加了新的化合物，并验证了它们在重金属离子检测中的高灵敏度和选择性。