Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. Thus, lysosomes play important roles in cellular activity. In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. Therefore, identifying the factors and mechanisms that regulate the functional status and spatial distribution of lysosomes and elucidating the relationship between lysosomes and the development and progression of cancer can provide important information for cancer diagnosis and prognosis prediction and may yield new therapeutic targets. This study briefly reviews the above information and explores the potential value of lysosomes in cancer therapy.

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溶酶体在癌症发展和进程中的作用

溶酶体是内膜系统的重要组成部分，并参与许多细胞生物学过程，例如大分子降解，抗原呈递，细胞内病原体破坏，质膜修复，外泌体释放，细胞粘附/迁移和凋亡。因此，溶酶体在细胞活性中起重要作用。此外，以前的研究表明，溶酶体可能通过上述生物学过程在癌症的发展和进程中起重要作用，并且溶酶体的功能状态和空间分布与癌细胞的增殖，能量代谢，侵袭和转移，免疫逃逸密切相关。和肿瘤相关的血管生成。因此，识别调节溶酶体功能状态和空间分布的因素和机制，阐明溶酶体与癌症发生和发展之间的关系可以为癌症诊断和预后预测提供重要信息，并可能产生新的治疗靶标。这项研究简要回顾了以上信息，并探讨了溶酶体在癌症治疗中的潜在价值。