Cp*Co(III) and Cu(OAc)2 bimetallic catalysis for Buchwald-type C–N cross coupling of aryl chlorides and amines under base, inert gas & solvent-free conditions,Green Chemistry

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Cp*Co(III) and Cu(OAc)2 bimetallic catalysis for Buchwald-type C–N cross coupling of aryl chlorides and amines under base, inert gas & solvent-free conditions
Green Chemistry ( IF 9.3 ) Pub Date : 2020-11-04 , DOI: 10.1039/d0gc02819c
Avinash K. Srivastava _{1,

2,

3,

4} , Charu Sharma _{1,

2,

3,

4} , Raj K. Joshi _{1,

2,

3,

4}

Affiliation

A strategy involving bimetallic catalysis with a combination of Cp*Co(CO)I₂ and Cu(OAc)₂ was used for performing Buchwald-type C–N coupling reactions of aryl chlorides with amines. The reactions proceeded at 100 °C to produce excellent yields of many of the desired C–N coupled products, in 4 h, under aerobic reaction conditions. The reactions were shown to run under base-free and solvent-free conditions, enabling this strategy to work efficiently for electron-withdrawing and base-sensitive functionalities. The presented methodology was found to be equally efficient for electron-donating functionalities as well as for primary (1°) and secondary (2°) aromatic and aliphatic amines. Moreover, the products were easily separated through the extractions of the organic aqueous layer, with this process chromatographic separations is not required.

中文翻译：

Cp * Co（III）和Cu（OAc）2双金属催化在碱，惰性气体和无溶剂条件下芳基氯化物和胺的布赫瓦尔德型C–N交叉偶联

一种将Cp * Co（CO）I ₂和Cu（OAc）₂结合使用的双金属催化策略，用于进行芳基氯化物与胺的布赫瓦尔德型C–N偶联反应。在好氧反应条件下，反应在100°C下进行，在4小时内产生了许多所需的C-N偶联产物的优异产率。反应显示在无碱和无溶剂条件下进行，使该策略可有效用于吸电子和对碱敏感的功能。发现所提出的方法对于给电子功能以及初级（1°）和次级（2°）芳香族和脂肪族胺。此外，通过有机水层的萃取可以容易地分离出产物，因此不需要色谱分离。

更新日期：2020-11-18

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