Baclofen (BAC, (R/S)-4-amino-3-(4-chlorophenyl)butanoic acid), was used to form multicomponent crystals (MCCs) with coformers (CFs) of different acidic strength and molecular size. The crystallisation of BAC with oxalic acid (OXA), salicylic acid (SAL), phenoxyacetic acid (POA), 2,4-dichlorophenoxyacetic acid (2,4ClPOA), 4-picoline (4PIC) and 3,4-lutidine (3,4LUT) yielded seven MCCs. The bulk materials were analysed by thermoanalytical methods (thermogravimetry and differential scanning calorimetry), powder X-ray diffraction analysis and Fourier transform infrared spectrometry. Liquid assisted grinding was also applied to form the MCCs. X-ray analysis of the single crystal structures revealed that BAC exists in zwitterionic or cationic form, and the MCCs represent a large variety of crystal classes, such as salts, salt solvates, cocrystal salt solvates or solvates with different stoichiometry. It was noted that BAC appeared in many different conformations in the MCCs, but comparative crystal packing analysis revealed similarities in the packing arrangement of the MCCs. This structural feature can be used for crystal engineering purposes when MCCs of BAC are designed.

中文翻译：

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具有酸和碱的巴氯芬多组分晶体—构象柔性和合成子多功能性

巴氯芬（BAC，（R / S）-4-氨基-3-（4-氯苯基）丁酸）用于形成具有不同酸性强度和分子大小的共形成物（CF）的多组分晶体（MCC）。用草酸（OXA），水杨酸（SAL），苯氧乙酸（POA），2,4-二氯苯氧乙酸（2,4ClPOA），4-甲基吡啶（4PIC）和3,4-二甲基吡啶（3， 4LUT）产生了七个MCC。通过热分析方法（热重分析和差示扫描量热法），粉末X射线衍射分析和傅里叶变换红外光谱法分析散装材料。还应用了液体辅助研磨来形成MCC。对单晶结构进行X射线分析后发现，BAC以两性离子或阳离子形式存在，MCC代表多种晶体类型，例如盐，盐溶剂化物，共结晶盐溶剂化物或化学计量不同的溶剂化物。注意到BAC在MCC中以许多不同的构象出现，但是比较晶体堆积分析显示MCC的排列方式相似。设计BAC的MCC时，此结构特征可用于晶体工程目的。