The in vitro anti-inflammatory and skin moisturizing activities of Pilea martini (Levl.) Hand.-Mazz. were investigated on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and human immortalized keratinocytes. Chromatographic analysis was performed to identify the chemical composition of the extracts. Pilea martini extracts significantly suppressed LPS-induced nitric oxide, prostaglandin E₂, interleukin 6, and tumor necrosis factor α production in dose-dependent manners. In addition, the extracts inhibited LPS-induced inducible nitric oxide synthase and cyclooxygenase-2 proteins and their mRNA expression through causing a downregulation of nuclear factor-κB, activator protein 1, and mitogen-activated protein kinase signaling cascades. The extracts increased the production of hyaluronic acid levels and enhanced the expression levels of both filaggrin and serine palmitoyltransferase regulation. Liquid chromatography-mass spectroscopy analysis showed that the extracts contained 6 different compounds (malic acid, tryptophan, chlorogenic acid, caffeic acid, p-coumaric acid, and isoquercetin) that may contribute to their bioactivities. Taken together, Pilea martini extract showed remarkable promise as an anti-inflammatory and moisturizing agent.

玛蒂尼（Levl。）Hand.-Mazz的体外抗炎和保湿作用。研究了脂多糖（LPS）刺激的RAW264.7巨噬细胞和人类永生化角质形成细胞。进行色谱分析以鉴定提取物的化学组成。玛提尼（Pilea martini）提取物显着抑制LPS诱导的一氧化氮（前列腺素E _2），白介素6和肿瘤坏死因子α的产生具有剂量依赖性。此外，提取物还通过引起核因子-κB，激活蛋白1和有丝分裂原激活的蛋白激酶信号级联反应的下调来抑制LPS诱导的一氧化氮合酶和环氧合酶2蛋白及其mRNA表达。提取物增加了透明质酸水平的产生，并增强了丝蛋白和丝氨酸棕榈酰转移酶调节的表达水平。液相色谱-质谱分析表明，提取物中含有6种不同的化合物（苹果酸，色氨酸，绿原酸，咖啡酸，对香豆酸和异槲皮素），可能有助于它们的生物活性。总而言之，皮莱马提尼酒 提取物作为抗炎和保湿剂显示出非凡的前景。