Stress has deleterious effects on brain health and yet, the prognostic value of psychosocial stress regarding the most common types of dementias, including Alzheimer disease, is still unclear. The primary aim of this systematic review was to explore the association between psychosocial stress and late onset dementia. We classified 24articles from Medline, PsycINFO, CINAHL, and Web of Science, as pertaining toxic categories of psychosocial and trauma-related stress (low socio-economic status [SES] related inequalities, marital status, posttraumatic stress disorder, work stress, “vital exhaustion” [VE], and, combined stressors). Using the Quality of Prognosis Studies in Systematic Reviews tool, we judged the quality of evidence to be low. This systematic review provided some non-robust, yet suggestive evidence that the above psychosocial types of stress are associated with increased risk of dementia in later life. Future robust, longitudinal studies with repeated validated measures of psychosocial stress and dementiaare required to strengthen or refute these findings.

压力对大脑健康有有害影响，然而，心理社会压力对包括阿尔茨海默病在内的最常见痴呆类型的预后价值仍不清楚。本系统评价的主要目的是探讨社会心理压力与迟发性痴呆之间的关联。我们将来自 Medline、PsycINFO、CINAHL 和 Web of Science 的 24 篇文章分类为与心理社会和创伤相关压力（低社会经济地位 [SES] 相关的不平等、婚姻状况、创伤后应激障碍、工作压力、“重要的社会经济地位”）相关的有毒类别。疲惫”[VE]，以及组合压力源）。使用系统评价工具中的预后研究质量，我们判断证据质量较低。这项系统评价提供了一些不可靠但具有启发性的证据，表明上述社会心理类型的压力与晚年患痴呆症的风险增加有关。未来需要进行强有力的纵向研究，对社会心理压力和痴呆症进行反复验证的测量，以加强或反驳这些发现。