Background. Progressive increase of an aging population in Western countries will result in a growth of stroke prevalence. As many stroke survivors chronically show severe disability, increase in economic, social, and medical burden could be expected in the future. Objective and subjective measures of poststroke recovery are necessary to obtain predictive information, to improve the treatments, and to better allocate resources. Aim. To explore a measure of the temporal dimension of poststroke recovery, to search for predictive association with multiple clinical variables, and to improve tailoring of poststroke treatments. Method. In this observational monocentric cohort study, 176 poststroke inpatients at their first cerebrovascular event were consecutively enrolled. A novel measure based on the time needed to reach the main milestones of motor recovery was proposed. Moreover, two commonly used outcome measures, a measure of global functioning (Functional Independence Measure (FIM™)) and a measure of neurological poststroke deficit (Fugl-Meyer scale), were collected for the investigations of possible predictors. Results. The patients showed a substantial increase in Fugl-Meyer and FIM scores during the rehabilitative treatment. The acquisition of three milestones was significantly associated with female sex (autonomous standing), length of stay and Fugl-Meyer initial score (autonomous walking), and Fugl-Meyer initial score (functional arm). These findings provided quantitative data on motor milestone reacquisition in a sample of poststroke patients. It also demonstrated the value of the Fugl-Meyer score in predicting the acquisition of two motor milestones, relevant for daily life activities. Conclusion. Systematic recording of the timescale of poststroke recovery showed that motor milestone reacquisition happens, on average and when attainable, in less than 30 days in our sample of patients. The present study underscores the importance of the Fugl-Meyer score as a possible predictor for better improvement in reacquisition times of milestone functional recovery.

中文翻译：

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中风后恢复的里程碑和时间表：一项队列研究

背景。西方国家老龄化人口的逐步增加将导致中风患病率的增加。由于许多中风幸存者长期表现出严重残疾，预计未来经济、社会和医疗负担会增加。中风后恢复的客观和主观测量对于获得预测信息、改进治疗和更好地分配资源是必要的。瞄准。探索中风后恢复的时间维度的测量，寻找与多个临床变量的预测关联，并改进中风后治疗的定制。方法. 在这项观察性单中心队列研究中，连续招募了 176 名首次脑血管事件的卒中后住院患者。提出了一种基于达到运动恢复主要里程碑所需时间的新措施。此外，收集了两种常用的结果测量方法，即全局功能测量（功能独立测量（FIM™））和中风后神经功能缺损测量（Fugl-Meyer 量表），用于研究可能的预测因素。结果. 在康复治疗期间，患者的 Fugl-Meyer 和 FIM 评分显着增加。三个里程碑的获得与女性性别（自主站立）、停留时间和 Fugl-Meyer 初始评分（自主行走）和 Fugl-Meyer 初始评分（功能臂）显着相关。这些发现提供了中风后患者样本中运动里程碑重新获得的定量数据。它还证明了 Fugl-Meyer 评分在预测获得与日常生活活动相关的两个运动里程碑方面的价值。结论. 中风后恢复时间尺度的系统记录表明，在我们的患者样本中，平均而言，如果可以达到，运动里程碑重新获得发生在不到 30 天的时间内。本研究强调了 Fugl-Meyer 评分作为更好地改善里程碑功能恢复的重新获得时间的可能预测指标的重要性。