All-Optical Brain Thermometry in Freely Moving Animals,ACS Photonics

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All-Optical Brain Thermometry in Freely Moving Animals
ACS Photonics ( IF 6.5 ) Pub Date : 2020-11-18 , DOI: 10.1021/acsphotonics.0c00706
Ilya V. Fedotov _{1,

2,

3,

4,

5} , Maxim A. Solotenkov ₁ , Matvey S. Pochechuev ₁ , Olga I. Ivashkina _{6,

7,

8} , Sergei Ya. Kilin ₉ , Konstantin V. Anokhin _{6,

8} , Aleksei M. Zheltikov _{1,

2,

3,

4,

7}

Affiliation

We present all-optical high-resolution temperature measurements in the brain of freely behaving mice using an implantable thermometer that integrates a reconnectable two-section fiber-optic probe and a microcrystal of diamond with germanium-vacancy (GeV) centers. The local brain temperature is read out from the photoluminescence spectrum of GeV centers coupled to the guided modes of the optical fiber implanted in a mouse brain. This fiber thermometer is shown to enable brain temperature measurements with an accuracy within 0.15 °C at a level of laser power low enough to keep laser-induced heating of the brain well below 0.1 °C.

中文翻译：

自由移动动物的全光学大脑测温

我们目前使用植入式温度计在行为自由的小鼠的大脑中进行全光学高分辨率温度测量，该温度计集成了可重新连接的两段式光纤探头和具有锗空位（GeV）中心的钻石微晶。从GeV中心的光致发光光谱中读取局部大脑温度，该GeV中心与植入小鼠脑中的光纤的引导模式耦合。该光纤温度计可在低至足以将激光诱导的大脑发热保持在0.1°C以下的低激光功率水平下，以0.15°C以内的精度进行大脑温度测量。

更新日期：2020-12-16

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