Biocompatible Magnesium Implant Double-Coated with Dexamethasone-Loaded Black Phosphorus and Poly(lactide-co-glycolide),ACS Applied Bio Materials

当前位置： X-MOL 学术 › ACS Appl. Bio Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Biocompatible Magnesium Implant Double-Coated with Dexamethasone-Loaded Black Phosphorus and Poly(lactide-co-glycolide)
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-11-18 , DOI: 10.1021/acsabm.0c01179
Jung Ho Lee ₁ , Seung Mi Baek ₁ , Gibum Lee ₁ , Seong-Jong Kim ₁ , Hyoung Seop Kim ₁ , Sei Kwang Hahn ₁

Affiliation

Magnesium (Mg) and its alloys have presented a paradigm for biodegradability in the field of biomedical devices. However, biodegradation of Mg and its alloys cause the formation of hydrogen gas and basic molecules in the body. Here we developed a surface modification method for Mg implants by double-coating with osteogenic dexamethasone (Dex)-loaded black phosphorus (BP) and poly(lactide-co-glycolide) (PLGA). According to electrochemical and biodegradation tests, the prepared Mg-Dex/BP/PLGA showed remarkably enhanced resistance against corrosion possibly by the neutralization of basic molecules from Mg implants with acidic molecules from BP and PLGA with increasing biodegradation. Scanning electron microscopy, cell proliferation tests, Alizarin Red staining, and alkaline phosphatase activity tests confirmed that MC3T3-E1 cells significantly proliferated and were differentiated on the Mg-Dex/BP/PLGA surface. Taken together, the facile surface modification of Mg implants could be effectively harnessed for protecting the Mg surface from corrosion and inducing the osseointegration of preosteoblasts onto the Mg implant.

中文翻译：

生物相容性镁植入物双涂层地塞米松黑磷和聚（丙交酯-共-乙交酯）

镁 (Mg) 及其合金在生物医学设备领域为生物降解性提供了范例。然而，镁及其合金的生物降解会导致体内形成氢气和碱性分子。在这里，我们开发了一种镁种植体的表面改性方法，通过双涂层载有成骨地塞米松 (Dex) 的黑磷 (BP) 和聚丙交酯共-乙交酯）（PLGA）。根据电化学和生物降解试验，制备的 Mg-Dex/BP/PLGA 显示出显着增强的抗腐蚀能力，这可能是由于 Mg 植入物的碱性分子与 BP 和 PLGA 的酸性分子中和，随着生物降解的增加。扫描电镜、细胞增殖试验、茜素红染色和碱性磷酸酶活性试验证实 MC3T3-E1 细胞显着增殖并在 Mg-Dex/BP/PLGA 表面分化。总之，镁植入物的表面改性可以有效地保护镁表面免受腐蚀并诱导前成骨细胞骨整合到镁植入物上。

更新日期：2020-12-21

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11