Cell Death and Differentiation ( IF 13.7 ) Pub Date : 2020-11-18 , DOI: 10.1038/s41418-020-00665-z Joep Sprangers 1, 2 , Irene C Zaalberg 1, 2 , Madelon M Maurice 1, 2
|
The intestinal epithelium harbors a remarkable adaptability to undergo injury-induced repair. A key part of the regenerative response is the transient reprogramming of epithelial cells into a fetal-like state, which drives uniform proliferation, tissue remodeling, and subsequent restoration of the homeostatic state. In this review, we discuss how Wnt and YAP signaling pathways control the intestinal repair response and the transitioning of cell states, in comparison with the process of intestinal development. Furthermore, we highlight how organoid-based applications have contributed to the characterization of the mechanistic principles and key players that guide these developmental and regenerative events.
中文翻译：
基于类器官的肠道发育、再生和修复建模
肠上皮对损伤引起的修复具有显着的适应性。再生反应的一个关键部分是上皮细胞短暂重编程为胎儿样状态，从而驱动均匀增殖、组织重塑以及随后的稳态恢复。在这篇综述中，我们讨论了 Wnt 和 YAP 信号通路如何控制肠道修复反应和细胞状态的转变，并与肠道发育过程进行比较。此外，我们强调了基于类器官的应用如何有助于描述指导这些发育和再生事件的机械原理和关键参与者。
京公网安备 11010802027423号