Aim 

To assess the prevalence and prognostic significance of NI-LGE in patients undergoing stress-CMR.

Methods 

Stress-CMR with either dipyridamole or adenosine was performed in 283 patients (228 men, 81%) including perfusion imaging, wall motion evaluation and LGE. Follow-up was completed in all enrolled patients (median time: 1850 days; interquartile range: 1225–2705 days). Composite endpoint included cardiac death, ventricular tachycardia, myocardial infarction, stroke, hospitalization for cardiac cause and coronary revascularization performed beyond 90 days from stress-CMR scans.

Results 

One hundred and twelve patients (40%) had negative LGE (no-LGE), 140 patients (49%) I-LGE and 31 patients (11%) NI-LGE. Twenty-five events occurred in the no-LGE group, 68 in I-LGE and 11 in the NI-LGE group. On survival curves, patients with NI-LGE had worse prognosis than patients with no-LGE regardless of the presence of inducible perfusion defects. No significant prognostic differences were found between I-LGE and NI-LGE.

Conclusion 

NI-LGE can be detected in 11% of patients during stress-CMR providing a diagnosis of nonischemic cardiac disease. Patients with NI-LGE have worse prognosis than those with no-LGE.

中文翻译：

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非缺血晚期g增强对应激性心脏磁共振的患病率和预后影响

目标 

评估承受压力CMR的患者中NI-LGE的患病率和预后意义。

方法 

283例患者（228名男性，占81％）中使用潘生丁或腺苷进行了压力CMR，包括灌注成像，壁运动评估和LGE。所有入组患者均完成了随访（中位时间：1850天；四分位间距：1225-1705天）。综合终点包括从应激CMR扫描开始超过90天的心脏死亡，室性心动过速，心肌梗塞，中风，因心脏病住院和冠状动脉血运重建。

结果 

112名患者（40％）的LGE（无LGE）阴性，140名患者（49％）的I-LGE和31名患者（11％）的NI-LGE。无LGE组发生25起事件，I-LGE组发生68起事件，NI-LGE组发生11起事件。在生存曲线上，无论是否存在可诱导的灌注缺陷，NI-LGE患者的预后均比非LGE患者差。I-LGE和NI-LGE之间没有发现明显的预后差异。

结论 

在应激性CMR期间可在11％的患者中检测到NI-LGE，可诊断出非缺血性心脏病。NI-LGE患者的预后比非LGE患者差。