Abstract

The immunological synapse promotes receptors and ligands interaction in the contact interface between the T lymphocyte and the antigen presenting cell; glycosylation of the proteins involved in this biological process favors regulation of molecular interactions and development of the T lymphocyte effector response. Glycans in the immunological synapse influence cellular and molecular processes such as folding, expression, and structural stability of proteins, they also mediate ligand-receptor interaction and propagation of the intracellular signaling or inhibition of uncontrolled cellular activation that could lead to the development of autoimmunity, among others. It has been suggested that altered glycosylation of proteins that participate in the immunological synapse affects the signaling processes and cell proliferation, as well as exacerbation of the effector mechanisms of T cells that trigger systemic damage and autoimmunity. Understanding the role of glycans in the immune response has allowed for advances in the development of immunotherapies in different fields through the controlled and specific activation of the immune response. This review describes the structural and biological aspects of glycans associated with some molecules present in the immunological synapse, providing information that allows understanding the function of glycosylation in the interaction between the T lymphocyte and the antigen-presenting cell, as well as its impact on signaling and development regulation of T lymphocytes effector response.

摘要

免疫突触在T淋巴细胞与抗原呈递细胞的接触界面中促进受体和配体的相互作用；参与该生物过程的蛋白质的糖基化有利于调节分子相互作用和 T 淋巴细胞效应反应的发展。免疫突触中的聚糖影响细胞和分子过程，如蛋白质的折叠、表达和结构稳定性，它们还介导配体-受体相互作用和细胞内信号传导或抑制不受控制的细胞激活，这可能导致自身免疫的发展，其中。有人提出，参与免疫突触的蛋白质的糖基化改变会影响信号传导过程和细胞增殖，以及触发全身性损伤和自身免疫的 T 细胞效应机制的恶化。了解聚糖在免疫反应中的作用，通过控制和特异性激活免疫反应，促进了不同领域免疫疗法的发展。这篇综述描述了与免疫突触中存在的一些分子相关的聚糖的结构和生物学方面，提供了有助于理解糖基化在 T 淋巴细胞和抗原呈递细胞之间相互作用中的功能的信息，以及它对信号传导的影响T淋巴细胞效应反应的发育调控。了解聚糖在免疫反应中的作用，通过控制和特异性激活免疫反应，促进了不同领域免疫疗法的发展。这篇综述描述了与免疫突触中存在的一些分子相关的聚糖的结构和生物学方面，提供了有助于理解糖基化在 T 淋巴细胞和抗原呈递细胞之间相互作用中的功能的信息，以及它对信号传导的影响T淋巴细胞效应反应的发育调控。了解聚糖在免疫反应中的作用，通过控制和特异性激活免疫反应，促进了不同领域免疫疗法的发展。这篇综述描述了与免疫突触中存在的一些分子相关的聚糖的结构和生物学方面，提供了有助于理解糖基化在 T 淋巴细胞和抗原呈递细胞之间相互作用中的功能的信息，以及它对信号传导的影响T淋巴细胞效应反应的发育调控。