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Copper/GanPhos-Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides: An Efficient Access to Chiral Pyrrolidine Spirocycles
Synthesis ( IF 2.2 ) Pub Date : 2020-11-17 , DOI: 10.1055/s-0040-1706599 Zhenjie Gan 1 , Er-Qing Li 2 , Ke Li 2 , Hui Zhang 2
中文翻译：
铜/ GanPhos催化的偶氮甲胺叶立德的1,3-偶极环加成反应：手性吡咯烷螺环的有效获取。
更新日期：2020-11-18
Synthesis ( IF 2.2 ) Pub Date : 2020-11-17 , DOI: 10.1055/s-0040-1706599 Zhenjie Gan 1 , Er-Qing Li 2 , Ke Li 2 , Hui Zhang 2
Affiliation
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A highly efficient copper/GanPhos-catalyzed 1,3-dipolar cycloaddition of azomethine ylides is reported. This viable transformation provides a series of optically active spiro[dihydronaphthalene-2,3′-pyrrolidine]s, bearing one spiro quaternary and three tertiary stereogenic centers, in good yields and with high ee values. This protocol features high diastereo- and enantioselectivity, broad substrate scope and mild reaction conditions.
中文翻译：
铜/ GanPhos催化的偶氮甲胺叶立德的1,3-偶极环加成反应：手性吡咯烷螺环的有效获取。
据报道，高效的铜/ GanPhos催化偶氮甲亚胺的1,3-偶极环加成反应。这种可行的转化提供了一系列旋光性螺[dihydronaphthalene-2,3'-吡咯烷] s，带有一个螺四元和三个叔立体中心，收率高且ee值高。该方案具有非对映选择性和对映选择性高，底物范围广和反应条件温和的特点。
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