LRRK2 at the pre‐synaptic site: A 16‐years perspective,Journal of Neurochemistry

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LRRK2 at the pre‐synaptic site: A 16‐years perspective
Journal of Neurochemistry ( IF 4.2 ) Pub Date : 2020-11-18 , DOI: 10.1111/jnc.15240
Francesca Pischedda ₁ , Giovanni Piccoli ₁

Affiliation

Parkinson's disease is a common neurodegenerative disorder and is clinically characterized by bradykinesia, rigidity, and resting tremor. Missense mutations in the leucine‐rich repeat protein kinase‐2 gene (LRRK2) are a recognized cause of inherited Parkinson's disease. The physiological and pathological impact of LRRK2 is still obscure, but accumulating evidence indicates that LRRK2 orchestrates diverse aspects of membrane trafficking, such as membrane fusion and vesicle formation and transport along actin and tubulin tracks. In the present review, we focus on the special relation between LRRK2 and synaptic vesicles. LRRK2 binds and phosphorylates key actors within the synaptic vesicle cycle. Accordingly, alterations in dopamine and glutamate transmission have been described upon LRRK2 manipulations. However, the different modeling strategies and phenotypes observed require a critical approach to decipher the outcome of LRRK2 at the pre‐synaptic site.

中文翻译：

突触前位点的LRRK2：16年的前景

帕金森氏病是一种常见的神经退行性疾病，临床上以运动迟缓，僵硬和静息性震颤为特征。富含亮氨酸的重复蛋白激酶2基因（LRRK2）中的错义突变是公认的帕金森氏病的病因。LRRK2的生理和病理影响仍然不清楚，但是越来越多的证据表明，LRRK2协调了膜运输的各个方面，例如膜融合和囊泡形成以及沿肌动蛋白和微管蛋白轨道的运输。在目前的审查中，我们专注于LRRK2和突触小泡之间的特殊关系。LRRK2结合和磷酸化突触小泡周期内的关键角色。因此，已经在LRRK2操作中描述了多巴胺和谷氨酸盐传递的改变。然而，

更新日期：2020-11-18

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