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Obligatory role of Schwann cell‐specific erythropoietin receptors in erythropoietin‐induced functional recovery and neurogenic muscle atrophy after nerve injury
Muscle & Nerve ( IF 2.8 ) Pub Date : 2020-11-18 , DOI: 10.1002/mus.27121
M A Hassan Talukder 1 , Jung Il Lee 2 , John P. Hegarty 1 , Anagha A. Gurjar 1 , Mary O'Brien 1 , Zara Karuman 1 , Grant D. Wandling 1 , Prem Kumar Govindappa 1 , John C. Elfar 1
Affiliation  

Erythropoietin (EPO) promotes myelination and functional recovery in rodent peripheral nerve injury (PNI). While EPO receptors (EpoR) are present in Schwann cells, the role of EpoR in PNI recovery is unknown because of the lack of EpoR antagonists or Schwann cell‐specific EpoR knockout animals.

中文翻译:

雪旺细胞特异性促红细胞生成素受体在神经损伤后促红细胞生成素诱导的功能恢复和神经源性肌肉萎缩中的强制性作用

促红细胞生成素(EPO)促进啮齿动物周围神经损伤(PNI)的髓鞘形成和功能恢复。尽管雪旺细胞中存在EPO受体(EpoR),但由于缺乏EpoR拮抗剂或雪旺细胞特异性EpoR基因敲除动物,因此EpoR在PNI恢复中的作用尚不清楚。
更新日期:2021-01-21
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