Citrate Crosslinked Poly(Glycerol Sebacate) with Tunable Elastomeric Properties,Macromolecular Bioscience

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Citrate Crosslinked Poly(Glycerol Sebacate) with Tunable Elastomeric Properties
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-11-18 , DOI: 10.1002/mabi.202000301
Brandon B Risley ₁ , Xiaochu Ding _{1,

2} , Ying Chen ₁ , Paula G Miller ₁ , Yadong Wang ₁

Affiliation

Poly(glycerol‐sebacate) (PGS) is a biodegradable elastomer known for its mechanical properties and biocompatibility for soft tissue engineering. However, harsh thermal crosslinking conditions are needed to make PGS devices. To facilitate the thermal crosslinking, citric acid is explored as a crosslinker to form poly(glycerol sebacate citrate) (PGSC) elastomers. The effects of varying citrate contents and curing times are investigated on the mechanical properties, elasticity, degradation, and hydrophilicity. To examine the potential presence of unreacted citric acid, material acidity is monitored in relation to the citrate content and curing times. It is discovered that a low citrate content and a short curing time produce PGSC with tunable mechanical characteristics similar to PGS with enhanced elasticity. The materials demonstrate good cytocompatibility with human umbilical vein endothelial cells similar to the PGS control. The research study suggests that PGSC is a potential candidate for large‐scale biomedical applications because of the quick thermal crosslink and tunable elastomeric properties.

中文翻译：

具有可调弹性体性能的柠檬酸盐交联聚癸二酸甘油酯

聚（甘油-癸二酸酯）（PGS）是一种可生物降解的弹性体，以其软组织工程的机械性能和生物相容性而闻名。然而，制造 PGS 器件需要苛刻的热交联条件。为了促进热交联，研究了柠檬酸作为交联剂来形成聚（癸二酸柠檬酸甘油酯）（PGSC）弹性体。研究了不同柠檬酸盐含量和固化时间对机械性能、弹性、降解和亲水性的影响。为了检查是否存在未反应的柠檬酸，需要监测材料酸度与柠檬酸盐含量和固化时间的关系。研究发现，低柠檬酸盐含量和短固化时间可产生具有与 PGS 相似的可调机械特性的 PGSC，但弹性增强。该材料表现出与人脐静脉内皮细胞良好的细胞相容性，类似于 PGS 对照。该研究表明，由于快速热交联和可调节的弹性体特性，PGSC 是大规模生物医学应用的潜在候选者。

更新日期：2020-11-18

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