Numerical analysis of nanoparticle transport and deposition in a cynomolgus monkey nasal passage,International Journal for Numerical Methods in Biomedical Engineering

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Numerical analysis of nanoparticle transport and deposition in a cynomolgus monkey nasal passage
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.2 ) Pub Date : 2020-11-18 , DOI: 10.1002/cnm.3414
Jingliang Dong _{1,

2} , Jiawei Ma ₂ , Lin Tian ₂ , Kiao Inthavong ₂ , Kazuhide Ito ₃ , Jiyuan Tu ₂

Affiliation

Environmental exposure to toxic agents is commonly encountered by occupational and residential populations. However, in vivo exposure data in human subjects is limited by measurement and ethical restrictions. Monkey represents a suitable surrogate for human exposure studies, but the particle transport and deposition features in monkey airways are still not well understood. As a response to this research challenge, this paper presents a virtual exposure study that numerically investigated the nanoparticle transport process through a realistic cynomolgus monkey nasal airway. Particles with size of 1 nm to 1 μm were considered and the transport process was modelled by the Lagrangian discrete phase model. Overall and local deposition as well as particle dispersion along the airway were examined by using a variety of non‐dimensional parameters including combined diffusion parameter, deposition enhancement factor and particle flux enhancement factor. Consistent deposition patterns were observed in present and literature nasal models. Most particles tended to pass the nasal airway through certain spatial regions, including the middle section of the nasal valve, the lower half of the middle coronal plane, and the central regions of the choana. While naturally inhaled nanoparticles can hardly be delivered to the olfactory region as it is located apart from the mainstream with high particle flux. Research findings provide insight into nanoparticle inhalation exposure characteristics in the monkey airway and can contribute in formulating data extrapolation schemes between monkey and human airways.

中文翻译：

食蟹猴鼻道中纳米颗粒转运和沉积的数值分析

职业和居住人群通常会接触到有毒物质的环境暴露。然而，人类受试者的体内暴露数据受到测量和伦理限制的限制。猴子代表了人类暴露研究的合适替代品，但猴子气道中的颗粒传输和沉积特征仍不清楚。作为对这一研究挑战的回应，本文提出了一项虚拟暴露研究，该研究对纳米颗粒通过真实食蟹猴鼻气道的传输过程进行了数值研究。考虑了尺寸为 1 nm 至 1 μm 的粒子，并通过拉格朗日离散相模型对传输过程进行建模。通过使用各种无量纲参数（包括组合扩散参数、沉积增强因子和粒子通量增强因子）检查整体和局部沉积以及沿气道的粒子扩散。在现有和文献鼻模型中观察到一致的沉积模式。大多数颗粒倾向于通过某些空间区域通过鼻气道，包括鼻瓣的中间部分、中冠状平面的下半部分和后鼻孔的中央区域。而自然吸入的纳米颗粒很难被输送到嗅觉区域，因为它远离主流，具有高颗粒通量。

更新日期：2020-11-18

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