Novel Bioactive Polyketides Isolated from Marine Actinomycetes: An Update Review from 2013 to 2019,Chemistry & Biodiversity

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Novel Bioactive Polyketides Isolated from Marine Actinomycetes: An Update Review from 2013 to 2019
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-11-18 , DOI: 10.1002/cbdv.202000562
Silei Lu ₁ , Jiangming Wang ₁ , Ruilong Sheng ₂ , Yiwen Fang ₃ , Ruihua Guo _{1,

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Affiliation

Marine organism‐associated actinobacteria represent a valuable resource for marine drugs due to their abundant secondary metabolites. The special environments in the ocean, for instance, high salt, high pressure, low temperature and oligotrophy, not only adapt to survival of actinomycetes but also enhance molecular diversity of actinomycete secondary metabolites production, thus making marine actinomycetes important sources of marine‐based bioactive compounds, especially polyketides. Herein, we summarized the structures and pharmacological activities of polyketides from actinobacteria associated with marine organisms from 2013 to 2019; moreover, the main source species of actinomycetes were discussed as well. We expected that this review would be helpful for future in‐depth research and development of marine‐based bioactive polyketides.

中文翻译：

从海洋放线菌中分离出的新型生物活性聚酮化合物：2013 年至 2019 年的更新回顾

海洋生物相关放线菌因其丰富的次生代谢物而成为海洋药物的宝贵资源。海洋中高盐、高压、低温、贫营养等特殊环境，不仅适应放线菌的生存，而且增强了放线菌次生代谢产物的分子多样性，使海洋放线菌成为海洋生物活性物质的重要来源。化合物，尤其是聚酮化合物。在此，我们总结了 2013 年至 2019 年与海洋生物相关的放线菌聚酮化合物的结构和药理活性；此外，还讨论了放线菌的主要来源物种。我们预计该综述将有助于未来海洋生物活性聚酮化合物的深入研究和开发。

更新日期：2020-11-18

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