Discovery and Engineering of a Novel Baeyer‐Villiger Monooxygenase with High Normal Regioselectivity,ChemBioChem

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Discovery and Engineering of a Novel Baeyer‐Villiger Monooxygenase with High Normal Regioselectivity
ChemBioChem ( IF 2.6 ) Pub Date : 2020-11-17 , DOI: 10.1002/cbic.202000478
Guang-Xiang Zhang ₁ , Zhi-Neng You ₁ , Jia-Mei Yu ₁ , Yuan-Yang Liu ₁ , Jiang Pan ₁ , Jian-He Xu _{1,

2} , Chun-Xiu Li ₁

Affiliation

Structure‐controllable synthesis: Regioselectivity is essential in Baeyer‐Villiger monooxygenase‐mediated regiodivergent conversions of asymmetric ketones to generate esters in organic synthesis. A novel normal‐preferring BVMO from Gordonia sihwensis with superior regioselectivity (97 : 3) was identified, engineered, and employed to efficiently synthesize 9‐(nonanoyloxy)nonanoic acid from 10‐ketostearic acid derived from renewable plant oils.

中文翻译：

具有高正常区域选择性的新型 Baeyer-Villiger 单加氧酶的发现和工程化

结构可控合成：区域选择性在 Baeyer-Villiger 单加氧酶介导的不对称酮的区域发散转化中是必不可少的，以在有机合成中生成酯。鉴定、设计并用于从源自可再生植物油的 10-酮硬脂酸有效合成 9-（壬酰氧基）壬酸的来自Gordonia sihwensis 的新型正常偏好 BVMO，具有优异的区域选择性（97:3）。

更新日期：2020-11-17

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