当前位置: X-MOL 学术Psychiatry Res. Neuroimaging › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Alterations in gray matter volumes and intrinsic activity in the prefrontal cortex are associated with suicide attempts in patients with bipolar disorder
Psychiatry Research: Neuroimaging ( IF 2.1 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.pscychresns.2020.111229
Yimeng Zhao , Lifei Wang , Elliot K. Edmiston , Fay Y. Womer , Xiaowei Jiang , Feng Wu , Lingtao Kong , Yifang Zhou , Fei Wang , Yanqing Tang , Shengnan Wei

Bipolar disorder (BD) is associated with increased suicidal behavior. Understanding the neural features of suicide attempts (SA) in patients with BD is critical to preventing suicidal behavior. The prefrontal cortex (PFC) is a key region related to SA. In this study, forty BD patients with a history of SA (BD+SA), 70 BD patients without a history of SA (BD-SA), and 110 individuals in a healthy control (HC) group underwent structural magnetic resonance imaging (MRI) and resting-state functional MRI. We used voxel-based morphometry (VBM) and amplitude of low frequency fluctuations (ALFF) techniques to examine the gray matter volumes (GMVs) and ALFF values in the PFC. Compared with the HC group, both the BD+SA and BD-SA groups had lower GMVs and higher ALFF values in the medial PFC (MPFC), ventral PFC (VPFC), and dorsolateral PFC (DLPFC). The ALFF values in the MPFC, VPFC, and DLPFC in the BD+SA group were significantly higher than those in the BD-SA group. These findings suggest that BD patients with SA have intrinsic activity abnormalities in PFC regions. This provides potentially identifiable neuroimaging markers in BD patients with SA that could be used to increase our understanding of suicidal behavior.

中文翻译:

前额叶皮层灰质体积和内在活动的改变与双相情感障碍患者的自杀企图有关

双相情感障碍 (BD) 与自杀行为增加有关。了解 BD 患者自杀企图 (SA) 的神经特征对于预防自杀行为至关重要。前额叶皮层 (PFC) 是与 SA 相关的关键区域。在本研究中,40 名有 SA 病史的 BD 患者(BD+SA)、70 名无 SA 病史的 BD 患者(BD-SA)和健康对照组(HC)中的 110 名个体接受了结构磁共振成像(MRI) ) 和静息状态功能 MRI。我们使用基于体素的形态测量 (VBM) 和低频波动幅度 (ALFF) 技术来检查 PFC 中的灰质体积 (GMV) 和 ALFF 值。与 HC 组相比,BD+SA 和 BD-SA 组在内侧 PFC (MPFC)、腹侧 PFC (VPFC) 和背外侧 PFC (DLPFC) 中均具有较低的 GMV 和较高的 ALFF 值。BD+SA组MPFC、VPFC、DLPFC的ALFF值均显着高于BD-SA组。这些发现表明患有 SA 的 BD 患者在 PFC 区域具有内在活动异常。这为患有 SA 的 BD 患者提供了潜在的可识别神经影像标记,可用于增加我们对自杀行为的理解。
更新日期:2021-01-01
down
wechat
bug