Abstract A novel ferrocene-containing quaternary ammonium-type dialdehyde (Fc-(N+CHO)2) was synthesized and used as a cross-linking agent to prepare the gelatin/PVA composite hydrogel with pH and oxidation dual-responsiveness. The mechanical properties, thermal stability, morphology and swelling behavior of the hydrogel were fully studied. The hydrogel exhibited excellent oxidation and acid-triggered swelling (even decomposing) properties because of oxidation destruction of Fc in Fc-(N+CHO)2 and its acid-sensitive Schiff base cross-linkage with gelatin, which leads to the hydrogel as a smart carrier to load functional cargos in many fields including materials and medicine.

中文翻译：

---

新型含二茂二醛交联的pH/氧化双响应明胶/PVA复合水凝胶

摘要 合成了一种新型的含二茂铁的季铵型二醛(Fc-(N+CHO)2) 并作为交联剂制备了具有pH 和氧化双重响应性的明胶/PVA 复合水凝胶。充分研究了水凝胶的力学性能、热稳定性、形貌和溶胀行为。由于 Fc-(N+CHO)2 中 Fc 的氧化破坏及其与明胶的酸敏感性席夫碱交联，水凝胶表现出优异的氧化和酸引发溶胀（甚至分解）特性，这导致水凝胶作为智能载体，可装载材料、医药等多个领域的功能性货物。