This study aimed to evaluate the antioxidant capacity of phosphatidylserine liposome (PS) against oxidative stress due to Cyclosporine A (CsA) and their concurrent administration on the attenuation of immune response. The effect of oral PS was evaluated on biochemical and oxidative renal markers and histology of nephrotic rats receiving CsA. The effect of co-administration of PS with CsA was assessed on DTH (delayed-type hypersensitivity) reaction of immunized rats. The cytokine production of IL-2 (Interleukin-2) and IFN-γ (Interferon gamma) was measured in immunized rat's splenocytes. PS treatment significantly (P < 0.05) reduced Cr and BUN of serum and MDA (malondialdehyde) in kidney tissue, and increased SOD (superoxide dismutase) and CAT (Catalase) of kidney tissue in CsA-nephrotic rats. Histopathology indicated significantly (P < 0.05) nephrotoxicity improvement after 25-day treatment with PS. Furthermore, CsA plus PS administration significantly reduced DTH response and cytokine production in immunized rats. In conclusion, co-administration of CsA plus PS may overcome oxidative stress while improving the performance of organ transplantation or autoimmune therapy.

这项研究旨在评估磷脂酰丝氨酸脂质体（PS）对由于环孢菌素A（CsA）引起的氧化应激的抗氧化能力及其同时施用对减轻免疫反应的影响。评估口服PS对接受CsA的肾病大鼠的生化和氧化性肾脏标志物以及组织学的影响。评估了PS与CsA共同给药对免疫大鼠DTH（迟发型超敏反应）反应的影响。在免疫的大鼠脾细胞中测量IL-2（白介素-2）和IFN-γ（干扰素γ）的细胞因子产生。PS治疗显着（P <0.05）降低了CsA肾病大鼠的肾组织中的Cr和BUN和MDA（丙二醛），并增加了肾组织的SOD（超氧化物歧化酶）和CAT（过氧化氢酶）。组织病理学显着（P <0。05）用PS治疗25天后，肾毒性得到改善。此外，CsA加PS给药可显着降低免疫大鼠的DTH反应和细胞因子产生。总之，CsA和PS的共同给药可以克服氧化应激，同时改善器官移植或自身免疫疗法的性能。