The effect of early childhood exposure to traffic-related air pollution (TRAP) on the development of asthma remains unclear. The aim of this study was to clarify potential associations between TRAP (fine particulate matter, PM_2.5; nitrogen dioxide, NO₂; Benzene and total volatile organic pollutants, TVOCs) and childhood asthma by integrating the results from previous studies. Elsevier, LISTA (EBSCO) and Web of Science databases were searched for relevant studies. Adjusted odds ratio (OR) with corresponding 95% confidence interval (CI) for the association between traffic-related air pollutants and health effects were recovered from individual studies and summary effect estimates (meta-OR) were generated in Review Manager 5.3. Twenty-seven studies were included in the meta-analysis and the results showed that TRAP increased the risk of asthma among children: PM_2.5 (meta-OR=1.07, 95% CI:1.00-1.13), NO₂ (meta-OR=1.11, 95% CI:1.06-1.17), Benzene (meta-OR: 1.21, 95% CI:1.13-1.29) and TVOC (meta-OR:1.06, 95% CI: 1.03-1.10). Sensitivity analyses supported these findings. In addition, regional analysis showed that ORs of inorganic TRAP (PM_2.5 and NO₂) on the risk of childhood asthma were significantly higher in Asia than those in Europe and North America. Subsequent research should focus on the association between organic pollutants in TRAP and childhood asthma. Furthermore, the disentanglement between TRAP and other pollutant sources may be investigated in future studies.

早期暴露于交通相关空气污染（TRAP）对哮喘发展的影响尚不清楚。这项研究的目的是阐明TRAP（细颗粒物，PM _2.5；二氧化氮，NO _2）之间的潜在联系。; 综合先前研究的结果，得出苯和总挥发性有机污染物（TVOC）和儿童哮喘。搜索Elsevier，LISTA（EBSCO）和Web of Science数据库以进行相关研究。从个别研究中恢复了与交通相关的空气污染物与健康影响之间的关联的调整后的优势比（OR），具有相应的95％置信区间（CI），并且在Review Manager 5.3中生成了汇总影响估计值（meta-OR）。荟萃分析包括27项研究，结果表明TRAP增加了儿童哮喘的风险：PM _2.5（meta-OR = 1.07，95％CI：1.00-1.13），NO ₂（元-OR = 1.11，95％CI：1.06-1.17），苯（元-OR：1.21、95％CI：1.13-1.29）和TVOC（元-OR：1.06，95％CI：1.03-1.10）。敏感性分析支持了这些发现。此外，区域分析表明，无机TRAP（PM _2.5和NO ₂）对儿童哮喘风险的OR在亚洲显着高于欧洲和北美。随后的研究应集中在TRAP中有机污染物与儿童哮喘之间的关系。此外，TRAP与其他污染物源之间的纠缠可能会在未来的研究中进行研究。