Eurycomanone is a quassinoid compound that is derived from Eurycoma longifolia, and it is often used as an indicator to evaluate the active ingredients of Eurycoma longifolia. However, Eurycomanone has rarely been reported to have biological activity toward pests. In this study, we evaluated the antifeedant activity of eurycomanone against the diamondback moth(Plutella xylostella), with a non-selective AFC₅₀(the concentration that corresponds to 50% antifeedant action) value and selective AFC₅₀ of 17.5 mg/L and 14.2 mg/L, respectively, which were 2.1-fold (36.9 mg/L) and 2-fold (28.5 mg/L) lower than that of azadirachtin, respectively. In addition, eurycomanone was used to treat the roots of Brassica chinensis L. at a concentration of 100 µg/g for 72 h. The antifeedant index was found to reach 93% by tracking the leaves. After feeding with 20 µg/g eurycomanone, no pupae or eclosion were observed. To explore this mechanism, we used scanning electron microscopy to discover that eurycomanone could prevent the development of taste receptors on the maxillary palp of diamondback moth larvae. Additional electrophysiological measurements showed that eurycomanone exhibited excitatory action to the central taste neurons of diamondback moth and significantly inhibited the GABA_A receptor current. Eurycomanone exhibited significant activity as an antifeedant, inhibited growth and excelled at systemic absorption.

Eurycomanone是一种衍生于Eurycoma longifolia的quassinoid化合物，通常被用作评价Eurycoma longifolia活性成分的指标。然而，很少报道杜仲酮对害虫具有生物活性。在这项研究中，我们以非选择性AFC ₅₀（对应于50％拒食作用的浓度）值和17.5 mg / L和14.2的选择性AFC ₅₀值评估了eurycomanone对小菜蛾（Plutella xylostella）的拒食活性。分别比印za素降低2.1倍（36.9 mg / L）和2倍（28.5 mg / L）。此外，乙草胺被用来治疗浓度为100 µg / g的甘蓝型油菜72小时。通过跟踪叶片发现拒食指数达到93％。喂入20 µg / g的eurycomanone后，未观察到p或暗疮。为了探索这种机制，我们使用扫描电子显微镜发现了eurycomanone可以阻止小菜蛾幼虫上颚上味觉受体的发育。额外的电生理学测量表明，eurycomanone对小菜蛾的中央味觉神经元表现出兴奋作用，并显着抑制了GABA _A受体电流。杜仲酮显示出显着的抗饲料活性，抑制了生长，并在全身吸收方面表现出色。