Hypoxia is a feature of the solid tumor microenvironment that is associated with poor clinical outcomes in multiple tumor types. Hypoxia-induced factor-1 alpha (HIF-1α) is a master regulator of hypoxic adaption, has been demonstrated to modulate hypoxic gene expression profiling and signaling transduction networks, and is thus a potential therapeutic target. Despite hypoxic response signaling having being extensively studied, the involvement of long non-coding RNAs (lncRNAs) in the hypoxic response has become a new focus of attention. Emerging evidence has documented complex interactions between HIF-1α and lncRNAs, which contribute to the acquisition of multiple hallmarks of cancer. In this review, we focus on recent advances in the study of hypoxia and HIF-1α-regulated lncRNAs, and summarize the molecular mechanisms and functional outcomes of the interplay between lncRNAs and HIF-1α, which may provide important insights into cancer diagnosis and prognosis, enabling better control of cancer.

缺氧是实体瘤微环境的特征，与多种肿瘤类型的不良临床预后相关。低氧诱导因子-1α（HIF-1α）是低氧适应的主要调节剂，已被证明可调节低氧基因表达谱和信号转导网络，因此是潜在的治疗靶点。尽管已经对缺氧反应信号进行了广泛研究，但是长的非编码RNA（lncRNA）参与缺氧反应已成为新的关注焦点。越来越多的证据表明，HIF-1α和lncRNA之间存在复杂的相互作用，这有助于获得多种癌症标志。在这篇综述中，我们重点研究缺氧和HIF-1α调控的lncRNAs的最新进展，