A highly selective and sensitive photoelectrochemical (PEC) sensing platform was developed for kanamycin assay based on the aptamer modified sandwich-structured ZnCuInSe/Au/TiO2 nanowires. Sandwiched between the TiO2 nanowires and the ZnCuInSe quantum dot (QDs) layer, the Au nanoparticles (Au NPs) serves as a plasmonic photosensitizer and an electron relay, which expand the light absorption range and facilitates the charge transfer. Also, ZnCuInSe QDs, a broad spectrum photosensitizer can capture visible light, which enhance the photocurrent density response. Through the Au-S bond and Cu-S bond, the HS-aptamer were immobilized on the ZnCuInSe/Au/TiO2 nanowires as a recognition unit for kanamycin. The proposed sensing platform showed excellent assay performance for kanamycin with a linear response range from 0.2 to 250 nM, and high selectivity. By changing the recognizers, the proposed sensing platform could be easily extended to detect other biomolecules, and may have a promising application in bioanalysis.

中文翻译：

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基于 ZnCuInSe/Au/TiO2 夹层纳米线的光电化学生物传感器用于卡那霉素超灵敏检测

基于适体修饰的夹心结构 ZnCuInSe/Au/TiO2 纳米线，开发了一种高选择性和灵敏的光电化学 (PEC) 传感平台，用于卡那霉素测定。夹在 TiO2 纳米线和 ZnCuInSe 量子点 (QDs) 层之间的 Au 纳米颗粒 (Au NPs) 作为等离子体光敏剂和电子继电器，扩大了光吸收范围并促进了电荷转移。此外，ZnCuInSe QD 是一种广谱光敏剂，可以捕获可见光，从而增强光电流密度响应。通过Au-S键和Cu-S键，HS-适配体固定在ZnCuInSe/Au/TiO2纳米线上，作为卡那霉素的识别单元。所提出的传感平台对卡那霉素具有出色的检测性能，线性响应范围为 0.2 至 250 nM，并且具有高选择性。