A novel and efficient procedure for the generation of quinazolinone phosphonate derivatives employing the reaction of euparin, isatin or its derivatives, primary amines, dialkyl acetylenedicarboxylates, trimethyl phosphite or triphenyl phosphite, and acidic solution of hydrogen peroxide in aqueous media at ambient temperature under ultrasonic irradiation was developed. Without ultrasonic irradiation, the reaction does not proceed and agitation of the reaction mixture is difficult. Some advantages of this procedure are: short time of reaction, high yields of products, easy isolation of products.

中文翻译：

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超声辐射绿色合成新型膦酸酯衍生物

一种新的和有效的程序用于采用euparin的反应喹唑啉酮膦酸酯衍生物的生成，靛红或其衍生物，伯胺，二烷基acetylenedicarboxylates，亚磷酸三甲酯或亚磷酸三苯酯，并且在环境温度超声波照射下在含水介质中的过氧化氢的酸性溶液已开发。没有超声照射，反应就不会进行，并且反应混合物难以搅拌。该方法的一些优点是：反应时间短，产物的产率高，产物易于分离。