Breast cancer is the second leading cause of cancer-related death among females, worldwide. The cytokines are proteins that have a significant role in the development of tumor growth. Leukemia inhibitory factor (LIF) of the interleukin-6 cytokines superfamily plays a significant role, by the modulation of many signaling pathways. This study summarizes some current works in breast cancer, in which LIF intervention is being discussed. LIF promotes tumorigenesis, invasion, migration of breast cancer cells in vitro , metastasis of breast cancer in vivo, epithelial-mesenchymal transition, and mediates pro-invasive activation of stromal fibroblast. LIF contributes to inducing growth, tumorigenesis, and metastasis of breast cancer and is a significant biomarker for breast tumors and can be a therapeutic target for clinical intervention.

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白血病抑制因子：乳腺癌的主要控制者

乳腺癌是全球女性癌症相关死亡的第二大原因。细胞因子是在肿瘤生长的发展中具有重要作用的蛋白质。白细胞介素 6 细胞因子超家族的白血病抑制因子 (LIF) 通过调节许多信号通路发挥重要作用。本研究总结了目前在乳腺癌方面的一些工作，其中正在讨论 LIF 干预。LIF 促进体外乳腺癌细胞的肿瘤发生、侵袭、迁移，体内乳腺癌的转移，上皮间质转化，并介导基质成纤维细胞的促侵袭激活。LIF 有助于诱导乳腺癌的生长、肿瘤发生和转移，是乳腺肿瘤的重要生物标志物，可以成为临床干预的治疗靶点。