In recent decades, the creation of new pharmaceutical targeted drug delivery has become widespread. In this regard, various carriers of medicinal substances have been developed. It is worthy to note that niosomes are more prospective in comparison with other carrier, because they are not susceptible to oxidation and they have delayed clearance, thus providing high therapeutic performance. This study aims to investigate some rheological properties of niosomal dispersion and the analysed dependence of viscosity coefficient on volume concentration. The results demonstrated that for low concentrations of niosomal dispersions, the dynamic viscosity coefficient can be estimated using the Einstein’s equation with the introduction of a correction factor, the value of which at an average diameter of 90–100 nm and a zeta potential of 49.5–54.5 mV is 0.04–0.05. It is wished that our work would be helpful to fully understand the structure of niosome aggregates, which are considered to play an important role in viscosity and are affected by both intermolecular and electrostatic forces. With increasing particle concentration and decreasing average distance between aggregates, the particles at the surface of different aggregates attract each other and a less compact aggregation structure is formed. The measured relationships between size, ζ-potential, and the relative viscosities of dispersions show that the relative viscosities decrease with decreasing absolute value of ζ-potential, which further reveals the effect of electrical repulsion forces on the structure of aggregates.

在最近的几十年中，新的靶向药物递送的药物的产生已变得广泛。在这方面，已经开发了各种药用物质载体。值得注意的是，与其他载体相比，脂质体更具有前瞻性，因为它们不易被氧化并且清除延迟，因此具有很高的治疗性能。这项研究的目的是研究纳米颗粒分散体的一些流变特性，并分析粘度系数对体积浓度的依赖性。结果表明，对于低浓度的染色体分散体，可以通过使用爱因斯坦方程并引入校正因子来估算动态粘度系数，该校正因子的值在平均直径为90-100 nm且ζ电位为49.5-的范围内。 54.5 mV为0.04-0。05.希望我们的工作将有助于充分理解脂质体聚集体的结构，这些聚集体被认为在粘度中起着重要作用，并且受分子间和静电力的影响。随着颗粒浓度的增加和聚集体之间平均距离的减小，不同聚集体表面的颗粒相互吸引，从而形成了较不紧密的聚集结构。尺寸之间的测量关系 不同聚集体表面的颗粒相互吸引，形成了较不紧密的聚集结构。尺寸之间的测量关系 不同聚集体表面的颗粒相互吸引，形成了较不紧密的聚集结构。尺寸之间的测量关系ζ电位和分散体的相对粘度表明，随着ζ电位绝对值的减小，相对粘度降低，这进一步揭示了电排斥力对聚集体结构的影响。