The pathophysiological changes in cells are mainly focusing on the ionic regulations like hyperpolarization, depolarization etc. The real-time monitoring of these changes in ionic behavior is one of the challenging areas in the biosensor field. A field-effect transistor (FET) based sensor system shows an exceptional advantage in noninvasive real-time monitoring of cellular changes. In this study, we monitored cell proliferation in real-time by using the FET biosensor. Cells were cultured on the FET sensing surface and the potential difference was monitored using the Electric-double-layer field-effect transistor (EDL-FET) biosensor system. Cell proliferation in the sensor surface was electrically measured as drain current change. The impedance measurement changes revealed the capacitive equivalent model of the FETs system. The most important factor in a cell-based system is to overcome the limited life span of cells in sensor platforms. This sensor platform was capable of monitoring cell growth and proliferation, compared with other conventional and current cell sensor platforms. Rapid electrical response corresponding to the cell growth and other functional changes associated with the cell can be used in many fields, including medicine, environmental monitoring and drug screening.

细胞的病理生理变化主要集中在离子调控上，例如超极化，去极化等。实时监测这些离子行为的变化是生物传感器领域的挑战之一。基于场效应晶体管（FET）的传感器系统在非侵入性实时监测细胞变化方面显示出显着优势。在这项研究中，我们通过使用FET生物传感器实时监测细胞增殖。将细胞培养在FET感应表面上，并使用双电层场效应晶体管（EDL-FET）生物传感器系统监控电势差。电测量传感器表面中的细胞增殖作为漏极电流的变化。阻抗测量的变化揭示了FET系统的等效电容模型。基于单元的系统中最重要的因素是克服传感器平台中单元的有限寿命。与其他常规和当前的细胞传感器平台相比，该传感器平台能够监视细胞的生长和增殖。对应于细胞生长和与细胞相关的其他功能变化的快速电响应可用于许多领域，包括医学，环境监测和药物筛选。