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In situ synthesis of superorganism-like Au NPs within microgels with ultra-wide absorption in visible and near-infrared regions for combined cancer therapy
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-11-5 , DOI: 10.1039/d0bm01618g
Shengtao Wang 1, 2, 3, 4, 5 , Anhe Wang 6, 7, 8, 9, 10 , Yuqi Ma 6, 7, 8, 9, 10 , Qingquan Han 1, 2, 3, 4, 5 , Yang Chen 1, 2, 3, 4, 5 , Xin Li 6, 7, 8, 9, 10 , Songyuan Wu 6, 7, 8, 9, 10 , Jieling Li 6, 7, 8, 9, 10 , Shuo Bai 6, 7, 8, 9, 10 , Jian Yin 1, 2, 3, 4, 5
Affiliation  

The whole is a collection of parts and fulfills specific functions that the parts do not have. In this work, 50 nm Au NPs were in situ synthesized and close packed into a superorganism-like superstructure by means of microgel 3D networks. The combined microgel is endowed with ultra-wide absorption in visible and near-infrared regions between 500 and 1100 nm in spite of Au NPs not having this property. The strong collective plasmon coupling between neighboring Au NPs induces high photothermal conversion efficiency of the microgel system under irradiation at various laser wavelengths. Due to the good loading capability, microgels with nanocomposites can also load photosensitive drugs simultaneously and be used for combined cancer treatments of photothermal therapy and photodynamic therapy.

中文翻译:

原位合成微凝胶中的超生物体样金纳米颗粒,在可见光和近红外区域具有超宽吸收,可用于联合癌症治疗

整体是零件的集合,并且完成了零件所没有的特定功能。在这项工作中,通过微凝胶3D网络原位合成了50 nm Au NP,并将其紧密堆积成类超生物。尽管Au NPs不具有这种特性,但结合的微凝胶在500至1100 nm之间的可见和近红外区域具有超宽吸收。相邻金纳米粒子之间的强集体等离激元偶合诱导了在各种激光波长照射下微凝胶系统的高光热转换效率。由于具有良好的负载能力,具有纳米复合材料的微凝胶还可以同时负载光敏药物,并可用于光热疗法和光动力疗法的联合癌症治疗。
更新日期:2020-12-16
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