Stem cell-based regenerative therapies hold great promises to treat a wide spectrum of diseases. However, stem cell engraftment and survival are still challenging due to an unfavorable transplantation environment. Advanced glycation end-products (AGEs) can contribute to the generation of these harmful conditions. AGEs are a heterogeneous group of glycated products, nonenzymatically formed when proteins and/or lipids become glycated and oxidized. Our typical Western diet as well as cigarettes contain high AGEs content. AGEs are also endogenously formed in our body and accumulate with senescence and in pathological situations. Whether AGEs have an impact on stem cell viability in regenerative medicine remains unclear, and research on the effect of AGEs on stem cell proliferation and apoptosis is still ongoing. Therefore, this systematic review provides a clear overview of the effects of glycated proteins on cell viability in various types of primary isolated stem cells used in regenerative medicine.

中文翻译：

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先进的糖基化终产物（AGEs）对原代干细胞增殖和凋亡的影响：系统评价

基于干细胞的再生疗法有望治疗多种疾病。然而，由于不利的移植环境，干细胞移植和存活仍然具有挑战性。晚期糖基化终产物（AGEs）可能会导致这些有害状况的产生。AGEs是糖基化产物的异质性基团，当蛋白质和/或脂质被糖基化和氧化时会以非酶形式形成。我们典型的西方饮食以及香烟都含有较高的AGEs含量。AGEs也是内源性地在我们体内形成，并随着衰老和病理情况而积累。AGEs是否对再生医学中的干细胞活力有影响尚不清楚，关于AGEs对干细胞增殖和凋亡的影响的研究仍在进行中。因此，