Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency caused by various intra- and extrapulmonary injury factors. Presently, excessive inflammation in the lung and the apoptosis of alveolar epithelial cells are considered to be the key factors in the pathogenesis of ALI. Hypoxia-inducible factor-1 (HIF-1) is an oxygen-dependent conversion activator that is closely related to the activity of reactive oxygen species (ROS). HIF-1 has been shown to play an important role in ALI and can be used as a potential therapeutic target for ALI. This manuscript will introduce the progress of HIF-1 in ALI and explore the feasibility of applying inhibitors of HIF-1 to ALI, which brings hope for the treatment of ALI.

中文翻译：

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低氧诱导因子-1：治疗急性肺损伤的潜在目标。

急性肺损伤（ALI）是由多种肺内和肺外损伤因素引起的急性低氧性呼吸功能不全。目前，肺部过度炎症和肺泡上皮细胞的凋亡被认为是ALI发病机理的关键因素。缺氧诱导因子1（HIF-1）是一种氧依赖性转化活化剂，与活性氧（ROS）的活性密切相关。已经显示出HIF-1在ALI中起重要作用，并且可以用作ALI的潜在治疗靶标。该手稿将介绍HIF-1在ALI中的研究进展，并探讨将HIF-1抑制剂应用于ALI的可行性，这为ALI的治疗带来了希望。