Invariant natural killer T cells (iNKT cells) are innate-like CD1d-restricted T cells that have NK cell–like properties and bear an invariant T cell receptor (iTCR). iNKT cells have shown potential for cancer immunotherapy. A study now shows that stabilization of the iTCR–CD1d complex via a single-chain bi-specific antibody stimulates iNKT cell–mediated anti-tumor immunity.

中文翻译：

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癌症中 iNKT 细胞的纳米接合剂

不变自然杀伤 T 细胞 (iNKT 细胞) 是先天样 CD1d 限制性 T 细胞，具有 NK 细胞样特性并带有不变 T 细胞受体 (iTCR)。iNKT 细胞已显示出用于癌症免疫治疗的潜力。现在的一项研究表明，通过单链双特异性抗体稳定 iTCR-CD1d 复合物可刺激 iNKT 细胞介导的抗肿瘤免疫。